The BBC News cited ZytoGen’s landmark 2012 paper demonstrating the ability of aCGH in PGS to improve the chances of a successful pregnancy:
“A study [by ZytoGen’s co-founders Zhihong Yang and Jiaen Liu], published in the journal Molecular Cytogenetics, suggests that extra genetic screening increases the pregnancy rate by 65%.”
The New York Times cited ZytoGen’s landmark 2012 paper demonstrating the ability of aCGH in PGS to improve the chances of a successful pregnancy:
“One study [by ZytoGen’s co-founders Zhihong Yang and Jiaen Liu] involving about 100 women under age 35 found that 71 percent of the women in the group whose embryos were tested became pregnant compared with 45.8 percent of those whose embryos were selected based only on their shape.”
PUBLICATIONS
Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, Peck AC, Sills ES, Salem RD. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet. 2012 May 2;5(1):24.
[Source] [PDF]
Liu J, Sills ES, Yang Z, Salem SA, Rahil T, Collins GS, Liu X, Salem RD. Array comparative genomic hybridization screening in IVF significantly reduces number of embryos available for cryopreservation. Clin Exp Reprod Med. 2012, 39:52-57.
[Source] [PDF]
Yang Z, Salem SA, Liu X, Kuang Y, Salem RD, Liu J. Selection of euploid
blastocysts for cryopreservation with array comparative genomic hybridization (aCGH) results in increased implantation rates in subsequent frozen and thawed embryo transfer cycles. Mol Cytogenet. 2013 Aug 9; 6(1):32.
[Source] [PDF]
Yang Z, Salem SA, Zhang J, Liu X, Kuang Y, Salem RD, Liu J. Selection of competent blastocysts for transfer by combining time-lapse and array CGH for patients undergoing preimplantation genetic diagnosis: a prospective study with sibling oocytes. BMC Med. Genom. 2014; 7:38
[Source] [PDF]
POSTERS
Yang Z, Zhang J, Liu X, Kuang Y, Liu J. Aneuploidy screening of human blastocysts from PGS patients using next generation sequencing: a pilot study. Presented at ESHRE 2014 30th Annual Meeting, 2014 Jul.
[Source/PDF]